Study Interval (Day)

0 mg/kg Control

8.0 mg/kg DOX

5.3 mg/kg DOX

3.5 mg/kg DOX

9.35 mg/kg DOX-O

6.5 mg/kg DOX-O

4.3 mg/kg DOX-O

13

28.0

28.8

27.2

28.0

26.8

27.7

27.4

17

27.6

26.6

25.9

26.5

24.3

26.0

26.7

20

27.9

25.7

25.2

26.1

23.7^a

25.9

26.7

24

28.4

22.0^a

24.2^a

25.4^b

21.4^a

25.3^b

25.9

26

29.6

20.0^a

23.9^a

26.2^b

20.0^a

26.0^b

27.2